Intramuscular progesterone optimizes live birth from programmed frozen embryo transfer: a randomized clinical trial
نویسندگان
چکیده
ObjectiveTo determine whether vaginal progesterone for programmed endometrial preparation is noninferior to intramuscular in terms of live birth rates from frozen embryo transfer (FET).DesignThree-armed, randomized, controlled noninferiority trial.SettingMulticenter fertility clinic.Patient(s)A total 1,346 volunteer subjects planning vitrified-warmed high-quality nonbiopsied blastocysts were screened, whom 1,125 ultimately enrolled and randomly assigned treatment.Intervention(s)The receive, FET, 50 mg daily (control group), 200 twice micronized plus every third day (combination treatment), or progesterone.Main Outcome Measure(s)The primary outcome was rate per transfer. The secondary outcomes a positive serum human chorionic gonadotropin test 2 weeks after biochemical pregnancy loss, clinical pregnancy, luteal concentration patient’s experience attitudes regarding the route administration, on basis survey administered between FET test.Result(s)A 1,060 FETs completed. significantly lower women receiving only (27%) than (44%) combination treatment (46%). Fifty percent pregnancies ended miscarriage.Conclusion(s)The vaginal-only replacement reduced, due primarily an increased miscarriage. Vaginal supplemented with progesterone, offering effective alternative regimen fewer injections.Clinical Trial Registration NumberNCT02254577. To (FET). Three-armed, trial. Multicenter clinic. A treatment. progesterone. test. injections.
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2021
ISSN: ['0015-0282', '1556-5653']
DOI: https://doi.org/10.1016/j.fertnstert.2021.04.013